Human Cancer Biology Recurrent Mutations of MYD88 and TBL1XR1 in Primary Central Nervous System Lymphomas
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چکیده
Purpose: Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance. Experimental Design: We investigated a series of 29 newly diagnosed, HIV-negative, PCNSL patients usinghigh-resolution single-nucleotide polymorphism (SNP) arrays (n1⁄429) andwhole-exome sequencing (n1⁄4 4) approaches. Recurrent homozygous deletions and somatic genemutations found were validated by quantitative real-time PCR and Sanger sequencing, respectively. Molecular results were correlated with
منابع مشابه
Recurrent mutations of MYD88 and TBL1XR1 in primary central nervous system lymphomas.
PURPOSE Our objective was to identify the genetic changes involved in primary central nervous system lymphoma (PCNSL) oncogenesis and evaluate their clinical relevance. EXPERIMENTAL DESIGN We investigated a series of 29 newly diagnosed, HIV-negative, PCNSL patients using high-resolution single-nucleotide polymorphism (SNP) arrays (n = 29) and whole-exome sequencing (n = 4) approaches. Recurre...
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PURPOSE Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin lymphoma confined to the central nervous system. Whether there is a PCNSL-specific genomic signature and, if so, how it differs from systemic diffuse large B-cell lymphoma (DLBCL) is uncertain. EXPERIMENTAL DESIGN We performed a comprehensive genomic study of tumor samples from 19 immunocompetent PCNSL patien...
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Little is known about the genomic basis of primary central nervous system lymphoma (PCNSL) tumorigenesis. To investigate the mutational profile of PCNSL, we analyzed nine paired tumor and germline DNA samples from PCNSL patients by high throughput exome sequencing. Eight genes of interest have been further investigated by focused resequencing in 28 additional PCNSL tumors to better estimate the...
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تاریخ انتشار 2012